Ru Cheng Selected Research

Maytansine (Maitansine)

10/2017	αvβ3 Integrin-targeted reduction-sensitive micellar mertansine prodrug: Superb drug loading, enhanced stability, and effective inhibition of melanoma growth in vivo.
7/2017	cRGD-installed docetaxel-loaded mertansine prodrug micelles: redox-triggered ratiometric dual drug release and targeted synergistic treatment of B16F10 melanoma.
1/2017	αvβ3 integrin-targeted micellar mertansine prodrug effectively inhibits triple-negative breast cancer in vivo.
11/2016	Glutathione-Sensitive Hyaluronic Acid-SS-Mertansine Prodrug with a High Drug Content: Facile Synthesis and Targeted Breast Tumor Therapy.

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Ru Cheng Research Topics

Disease

47	Neoplasms (Cancer) 07/2022 - 01/2009
7	Breast Neoplasms (Breast Cancer) 01/2021 - 05/2011
5	Melanoma (Melanoma, Malignant) 11/2020 - 07/2017
4	Lung Neoplasms (Lung Cancer) 01/2021 - 06/2015
4	Hepatocellular Carcinoma (Hepatoma) 03/2015 - 08/2013
3	Glioma (Gliomas) 01/2018 - 12/2014
2	Triple Negative Breast Neoplasms 12/2020 - 01/2017
2	Multiple Myeloma 01/2020 - 10/2018
2	Body Weight (Weight, Body) 07/2017 - 01/2017
1	Uterine Cervical Neoplasms (Cancer of the Cervix) 07/2022
1	Hepatitis B 04/2022
1	Neoplasm Metastasis (Metastasis) 12/2020
1	Colorectal Neoplasms (Colorectal Cancer) 10/2019
1	Hematologic Neoplasms (Hematological Malignancy) 10/2018
1	Peripheral Nervous System Diseases (PNS Diseases) 10/2018
1	Brain Neoplasms (Brain Tumor) 01/2018
1	Dyslipidemias (Dyslipidemia) 01/2018
1	Fibrosis (Cirrhosis) 01/2018
1	Inflammation (Inflammations) 01/2018
1	Hyperglycemia 01/2018
1	Leukemia 10/2017
1	Acute Myeloid Leukemia (Acute Myelogenous Leukemia) 10/2017
1	Liver Neoplasms (Liver Cancer) 03/2015
1	Glioblastoma (Glioblastoma Multiforme) 12/2014

Drug/Important Bio-Agent (IBA)

24	Pharmaceutical PreparationsIBA 07/2022 - 05/2011
17	MicellesIBA 01/2020 - 10/2009
13	Doxorubicin (Adriamycin)FDA LinkGeneric 10/2019 - 01/2009
9	ProdrugsIBA 10/2017 - 05/2011
8	Hyaluronic Acid (Hyaluronan)IBA 01/2021 - 05/2015
7	Ethylene Glycol (Monoethylene Glycol)IBA 01/2018 - 08/2013
5	Docetaxel (Taxotere)FDA Link 01/2021 - 07/2017
5	LigandsIBA 01/2018 - 10/2013
5	polyethylene glycol bis(succinimidyl succinate)IBA 01/2017 - 08/2013
4	Maytansine (Maitansine)IBA 10/2017 - 11/2016
4	NanogelsIBA 07/2017 - 05/2011
4	Proteins (Proteins, Gene)FDA Link 07/2017 - 08/2013
4	caprolactoneIBA 03/2015 - 08/2013
3	DisulfidesIBA 01/2021 - 10/2018
3	Matrix Metalloproteinases (MMPs)IBA 10/2017 - 01/2017
3	IntegrinsIBA 10/2017 - 12/2014
2	Thioctic Acid (Lipoic Acid)IBA 11/2020 - 05/2015
2	Proteasome InhibitorsIBA 01/2020 - 10/2018
2	Liposomes (Liposome)IBA 01/2018 - 04/2015
2	Peptides (Polypeptides)IBA 01/2018 - 07/2013
2	Cell-Penetrating PeptidesIBA 01/2018 - 01/2018
2	Methotrexate (Mexate)FDA LinkGeneric 01/2018 - 10/2016
2	AcidsIBA 01/2018 - 08/2013
2	Glutathione (Reduced Glutathione)IBA 10/2017 - 11/2016
2	Granzymes (Granzyme)IBA 07/2017 - 06/2015
2	cyanine dye 5IBA 01/2017 - 11/2016
2	sigma Receptors (sigma Receptor)IBA 10/2016 - 06/2015
2	carbopol 940 (sodium polyacrylate)IBA 05/2014 - 08/2013
2	Galactose (Galactopyranose)FDA LinkGeneric 10/2013 - 08/2013
2	PolymersIBA 10/2011 - 05/2011
1	Folic Acid (Vitamin M)FDA LinkGeneric 07/2022
1	Indicators and Reagents (Reagents)IBA 04/2022
1	MicroRNAs (MicroRNA)IBA 01/2021
1	NucleotidesIBA 01/2021
1	Biomarkers (Surrogate Marker)IBA 01/2021
1	NeuropilinsIBA 12/2020
1	Small Interfering RNA (siRNA)IBA 12/2020
1	Bevacizumab (Avastin)FDA Link 12/2020
1	acetyl- lysyl- prolyl- seryl- seryl- prolyl- prolyl- glutamyl- glutamic acid amideIBA 01/2020
1	carfilzomibIBA 01/2020
1	polytyrosineIBA 10/2019
1	Octoxynol (Triton X 100)IBA 10/2019
1	Surface-Active Agents (Surfactants)IBA 10/2019
1	Bortezomib (Velcade)FDA Link 10/2018
1	oil red OIBA 01/2018
1	Serotonin (5 Hydroxytryptamine)IBA 01/2018
1	Hematoxylin (Haematoxylon)IBA 01/2018
1	Angiopep-2IBA 01/2018
1	Reactive Oxygen Species (Oxygen Radicals)IBA 01/2018
1	Eosine Yellowish-(YS) (Eosin)IBA 01/2018
1	Mercaptopurine (6 Mercaptopurine)FDA LinkGeneric 10/2017
1	ethylene sulfide (thiirane)IBA 10/2017
1	cyclic arginine-glycine-aspartic acid peptideIBA 07/2017
1	ErbB Receptors (EGF Receptor)IBA 07/2017
1	indotricarbocyanineIBA 01/2017
1	IodidesIBA 01/2017
1	Coloring Agents (Dyes)IBA 01/2017
1	Ascorbic Acid (Vitamin C)FDA LinkGeneric 01/2017
1	Reducing AgentsIBA 01/2017
1	iodixanol (Visipaque)FDA Link 12/2016
1	Ado-Trastuzumab EmtansineIBA 11/2016
1	polyleucineIBA 09/2015
1	Glutamic Acid (Glutamate)FDA Link 09/2015
1	L-lysine methyl esterIBA 05/2015
1	Asialoglycoprotein ReceptorIBA 03/2015
1	Lactose FDA LinkGeneric 03/2015
1	MethacrylatesIBA 05/2014
1	lactobionic acid (lactobionate)IBA 03/2014
1	Paclitaxel (Taxol)FDA LinkGeneric 08/2013
1	AcetalsIBA 08/2013
1	Catechol O-Methyltransferase (Methyltransferase, Catechol)IBA 01/2013

Therapy/Procedure

28	Therapeutics 07/2022 - 10/2009
17	Drug Therapy (Chemotherapy) 01/2021 - 08/2013
1	Injections 01/2017
1	Precision Medicine 12/2016
1	Intravenous Injections 12/2016